LR3 insulin-like growth factor-1 (IGF-I) is a recombinant analog of human IGF-I containing the complete human IGF-I protein sequence with substitution of Arg for Glu3 and a 13 amino acid N-terminal extension peptide.
Insulin-like growth factor 1 (IGF-1), also known as somatomedin C, is a protein similar in structure to insulin. IGF-1 is a primary mediator of the effects of growth hormone (GH). IGF-1 then stimulates systemic body growth, and has growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic, and lung cells. In addition to the insulin-like effects, IGF-1 can also regulate cellular DNA synthesis.